GPR55 (CB3)

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You have done and will continue to do your own research; and

You do not hold this website or its' affiliates responsible for your health.

Everyone has the following fundamental freedoms:

(a) freedom of conscience and religion;
(b) freedom of thought, belief, opinion and expression, including freedom of the press and other media of communication;
(c) freedom of peaceful assembly; and
(d) freedom of association.

Everyone has the right to life, liberty and security of the person and the right not to be deprived thereof except in accordance with the principles of fundamental justice.

Before purchasing any product(s) from this site you agree that:

You are taking your health into your own hands;

You have done and will continue to do your own research; and

You do not hold this website or its' affiliates responsible for your health.

Everyone has the following fundamental freedoms:

(a) freedom of conscience and religion;
(b) freedom of thought, belief, opinion and expression, including freedom of the press and other media of communication;
(c) freedom of peaceful assembly; and
(d) freedom of association.

Everyone has the right to life, liberty and security of the person and the right not to be deprived thereof except in accordance with the principles of fundamental justice.

Before purchasing any product(s) from this site you agree that:

You are taking your health into your own hands;

You have done and will continue to do your own research; and

You do not hold this website or its' affiliates responsible for your health.

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CBD Reviews articles are not the view or opinion of Alpha Extract Administrators

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Pharmaceutical companies initially hoped chemicals acting on GPR 55 would reduce blood pressure, however rats bred to not have GPR 55 had no issues with blood pressure so drug development has stopped.

CBD is primarily an antagonist of GPR55 and stops its expression, leading to some of its physiological effects. It is poorly understood however, with its role in several areas of the body poorly understood.Pathophysiological relevance of GPR55 expression. Recent evidence suggests that GPR55 is involved in the control of a variety of physiological functions. In the nervous system, GPR55 regulates dorsal root ganglia excitability and controls inflammatory and neuropathic pain. In blood, GPR55 regulates neutrophil migration and may prevent oxidative damage. GPR55 is also involved in bone metabolism, specifically inducing bone resorption. Other studies have suggested additional roles for GPR55 in modulating vascular function [by inducing vasorelaxation and controlling angiogenesis, renal tubule hypertrophy, decidual tissue regression during pregnancy, and mast cell-mediated antiinflammatory actions. However, additional experimental evidence is required to support these hypotheses. Besides controlling these (and most probably many other) physiological functions, GPR55 seems to play an important role in cancer progression by modulating cancer cell proliferation and migration.

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